Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549548 | 0.77 | KCNJ1 (0.58) | KCNJ1KCNH2 | |
| SCHEMBL2731338 | 0.68 | KCNH2 (0.76) | KCNJ1KCNH2ALDH1A1HTTNPSR1 | |
| SCHEMBL4549632 | 0.66 | KCNJ1 (0.53) | KCNJ1KCNH2 | |
| SCHEMBL9731780 | 0.65 | KCNH2 (0.71) | KCNJ1KCNH2ALDH1A1HTTNPSR1 | |
| SCHEMBL8562251 | 0.62 | KCNH2 (0.78) | KCNJ1KCNH2ALDH1A1HTTNPSR1 | |
| SCHEMBL297835 | 0.62 | KCNJ1 (0.64) | KCNJ1KCNH2 | |
| SCHEMBL9733429 | 0.62 | KCNH2 (0.88) | KCNJ1KCNH2ALDH1A1HTTNPSR1 | |
| SCHEMBL15196841 | 0.62 | KCNJ1 (0.66) | KCNJ1KCNH2 | |
| SCHEMBL15196836 | 0.62 | KCNJ1 (0.51) | KCNJ1KCNH2 | |
| SCHEMBL15196953 | 0.62 | KCNJ1 (0.51) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |