Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | LATS1 | O95835 | 3/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549831 | 0.84 | STK17B (0.61) | STK17BSTK17ALATS1CKS1BSKP1 | |
| SCHEMBL15238226 | 0.82 | STK17B (0.45) | STK17BSTK17ALATS1LATS2SYK | |
| SCHEMBL19286909 | 0.82 | STK17B (0.48) | STK17BSTK17ASYKMAPKAPK2AAK1 | |
| SCHEMBL4549891 | 0.81 | STK17B (0.47) | STK17BSTK17ASYKMAPKAPK2AAK1 | |
| SCHEMBL29474436 | 0.81 | STK17B (0.54) | STK17BSTK17ALATS1LATS2PIM1 | |
| SCHEMBL2722686 | 0.81 | STK17B (0.54) | STK17BSTK17ALATS1LATS2PIM1 | |
| SCHEMBL4549828 | 0.79 | STK17B (0.48) | STK17BSTK17ASYKAAK1BRD4 | |
| SCHEMBL10082684 | 0.79 | STK17B (0.48) | STK17BSTK17ASYKAAK1BRD4 | |
| SCHEMBL4549907 | 0.79 | STK17B (0.45) | STK17BSTK17ASYKMAPKAPK2AAK1 | |
| SCHEMBL15298140 | 0.78 | STK17B (0.45) | STK17BSTK17ASYKMAPKAPK2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216792-A1 | LACTAM KINASE INHIBITORS | Tavares, Francis Xavier (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2831080-B1 | LACTAM KINASE INHIBITORS | TAVARES FRANCIS XAVIER (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-3118203-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2017-01-18 | — | — | EP | disclosed |
| EP-2632467-B1 | CDK INHIBITORS | G1 THERAPEUTICS INC (US) | 2016-06-22 | — | — | EP | disclosed |
| EP-2955183-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014144740-A2 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144326-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144847-A2 | HSPC-SPARING TREATMENTS FOR RB-POSITIVE ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013148748-A1 | LACTAM KINASE INHIBITORS | TAVARES FRANCIS XAVIER (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2012061156-A1 | CDK INHIBITORS | TAVARES FRANCIS X (US) | 2012-05-10 | — | — | WO | disclosed |