Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.45 |
| ▸ | GSK3A | P49840 | 8/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716932 | 0.90 | GSK3B (0.45) | GSK3BGSK3AJAK1AURKASYK | |
| SCHEMBL2716154 | 0.90 | GSK3B (0.47) | GSK3BGSK3AAURKASYKLCK | |
| SCHEMBL2716231 | 0.90 | GSK3B (0.45) | GSK3BGSK3AAURKASYKLCK | |
| SCHEMBL2716708 | 0.90 | GSK3B (0.45) | GSK3BGSK3AJAK1AURKASYK | |
| SCHEMBL2718565 | 0.89 | GSK3B (0.44) | GSK3BGSK3AJAK1AURKASYK | |
| SCHEMBL2715923 | 0.88 | GSK3B (0.44) | GSK3BGSK3ASYKIGF1RCNR2 | |
| SCHEMBL4550343 | 0.84 | GSK3B (0.60) | GSK3BGSK3AMAPT | |
| SCHEMBL2713486 | 0.84 | KLKB1 (0.46) | GSK3BGSK3ASYKKLKB1 | |
| SCHEMBL2713402 | 0.82 | GSK3B (0.37) | GSK3BGSK3AJAK1SYKMAPT | |
| SCHEMBL2716643 | 0.80 | ALDH1A1 (0.43) | GSK3BGSK3AJAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053186-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-04-26 | — | — | WO | disclosed |