Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | GSK3A | P49840 | 5/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714719 | 0.94 | GSK3B (0.50) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL4550806 | 0.91 | GSK3B (0.47) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL2715521 | 0.88 | GSK3B (0.46) | GSK3BMAPTGSK3ASCN9AL3MBTL1 | |
| SCHEMBL2717376 | 0.88 | GSK3B (0.46) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL2716580 | 0.88 | GSK3B (0.46) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL2716714 | 0.88 | GSK3B (0.45) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL2715858 | 0.88 | SCN9A (0.52) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL2713711 | 0.87 | GSK3B (0.47) | GSK3BMAPTGSK3ASCN9AL3MBTL1 | |
| SCHEMBL2718782 | 0.85 | GSK3B (0.51) | GSK3BMAPTGSK3ASCN9AKCNH2 | |
| SCHEMBL2716288 | 0.85 | GSK3B (0.61) | GSK3BMAPTGSK3ASCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053186-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-04-26 | — | — | WO | disclosed |