Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2409557 | 0.85 | MCHR1 (0.50) | MCHR1MAPTNPC1RAB9ALMNA | |
| SCHEMBL12142410 | 0.74 | CDK4 (0.44) | STAT6CDK4CCND1CCND2CCND3 | |
| SCHEMBL5856552 | 0.74 | KMT2A (0.62) | MCHR1MAPTKDM4ENAMPTPDE7A | |
| SCHEMBL17392707 | 0.74 | NOTUM (0.59) | NOTUMLMNAL3MBTL1PHGDH | |
| SCHEMBL3436548 | 0.74 | NOTUM (0.59) | NOTUMLMNAL3MBTL1PHGDH | |
| SCHEMBL6398487 | 0.74 | NOTUM (0.59) | NOTUMLMNAL3MBTL1PHGDH | |
| SCHEMBL2408095 | 0.72 | HDAC1 (0.66) | WDR91 | |
| SCHEMBL2413063 | 0.72 | HDAC1 (0.66) | WDR91 | |
| SCHEMBL2408090 | 0.72 | HDAC1 (0.66) | WDR91 | |
| SCHEMBL2406015 | 0.72 | NAMPT (0.52) | MCHR1MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134680-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008109994-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-09-18 | — | — | WO | disclosed |