Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551235 | 0.87 | MEN1 (0.50) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL4552270 | 0.86 | MEN1 (0.41) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL4551799 | 0.82 | MEN1 (0.42) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL4409606 | 0.76 | MEN1 (0.53) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL14473143 | 0.76 | MEN1 (0.53) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL5602271 | 0.74 | HTT (0.43) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL4552271 | 0.74 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL14473322 | 0.73 | MEN1 (0.44) | MEN1KMT2AMAPTPOLBHTT | |
| SCHEMBL14473168 | 0.72 | TEK (0.48) | MEN1KMT2APOLB | |
| SCHEMBL5604346 | 0.72 | HTT (0.42) | MEN1KMT2AMAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |