Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.52 |
| ▸ | BRAF | P15056 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592981 | 0.98 | RAF1 (0.54) | RAF1BRAFRAB9ANPC1MAPK14 | |
| SCHEMBL14473332 | 0.92 | RAB9A (0.51) | RAF1BRAFRAB9ANPC1MAPK14 | |
| SCHEMBL4551381 | 0.90 | RAB9A (0.53) | RAF1BRAFRAB9ANPC1 | |
| SCHEMBL4412542 | 0.89 | RAF1 (0.54) | RAF1BRAFMAPK14 | |
| SCHEMBL4566569 | 0.89 | RAF1 (0.55) | RAF1BRAFMAPK14 | |
| SCHEMBL5593171 | 0.89 | RAB9A (0.51) | RAF1BRAFRAB9ANPC1MAPK14 | |
| SCHEMBL5593491 | 0.89 | RAF1 (0.60) | RAF1BRAFRAB9ANPC1 | |
| SCHEMBL4551893 | 0.88 | RAF1 (0.54) | RAF1BRAFMAPK14 | |
| SCHEMBL4541481 | 0.87 | RAB9A (0.47) | RAF1BRAFRAB9ANPC1MAPK14 | |
| SCHEMBL5593266 | 0.87 | RAB9A (0.50) | RAF1BRAFRAB9ANPC1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |