Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GYPA | P02724 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701045 | 0.89 | HTT (0.44) | HTTCYP3A4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4552159 | 0.87 | HTT (0.41) | HTTCYP3A4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL12136563 | 0.84 | HTT (0.41) | HTTCYP3A4KMT2APDE4DGYPA | |
| SCHEMBL13595480 | 0.80 | HTT (0.54) | HTTKMT2APDE4DTSHRMAPK1 | |
| SCHEMBL1987154 | 0.80 | HTT (0.54) | HTTKMT2APDE4DTSHRMAPK1 | |
| SCHEMBL10564679 | 0.80 | HTT (0.54) | HTTKMT2APDE4DTSHRMAPK1 | |
| SCHEMBL4551396 | 0.79 | HTT (0.42) | HTTCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL5967919 | 0.75 | SLC1A3 (0.39) | HTTCYP3A4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL10562396 | 0.75 | SLC1A3 (0.39) | HTTCYP3A4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL12050573 | 0.73 | MEN1 (0.39) | HTTCYP3A4SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642644-B2 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY | 2009-12-24 | — | — | US | disclosed |
| EP-1812017-A2 | OPHTHAMOLOGICAL DRUGS | Duke University (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060135609-A1 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2006-06-22 | — | — | US | disclosed |
| WO-2006047466-A2 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135609-A1 | Ophthamological drugs | QDPR, PTGIR, PDE6C | HTT 412/4885CYP3A4 330/4885SLC1A3 1368/4885 |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | QDPR, PTGIR, PDE6C | HTT 475/4885CYP3A4 248/4885SLC1A3 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.