Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 7/20 | 0.51 |
| ▸ | BRAF | P15056 | 7/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5603999 | 0.98 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4410223 | 0.96 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4411272 | 0.95 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4551493 | 0.90 | NAMPT (0.43) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4541475 | 0.90 | RAF1 (0.56) | MAPK14RAF1BRAF | |
| SCHEMBL4413471 | 0.89 | RAF1 (0.58) | MAPK14RAF1BRAF | |
| SCHEMBL4551597 | 0.89 | MAPK14 (0.60) | MAPK14RAF1BRAFNAMPTTP53 | |
| SCHEMBL14473104 | 0.88 | RAF1 (0.52) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5603996 | 0.88 | NAMPT (0.45) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4408316 | 0.88 | MAPK14 (0.49) | MAPK14RAF1BRAFNAMPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |