Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5603996 | 0.98 | NAMPT (0.45) | NAMPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4551494 | 0.90 | MAPK14 (0.51) | NAMPTMAPK14TP53MAPK13MAPK12 | |
| SCHEMBL4541474 | 0.90 | RAF1 (0.42) | CYP3A4CYP2C9MAPK14RAF1BRAF | |
| SCHEMBL4551596 | 0.89 | NAMPT (0.54) | NAMPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5603999 | 0.88 | MAPK14 (0.53) | NAMPTMAPK14TP53MAPK13MAPK12 | |
| SCHEMBL5603875 | 0.87 | NAMPT (0.41) | NAMPTCYP1A2CYP3A4CYP2C9TP53 | |
| SCHEMBL4551892 | 0.86 | RAF1 (0.44) | MAPK14RAF1BRAF | |
| SCHEMBL4410223 | 0.86 | MAPK14 (0.47) | NAMPTMAPTMAPK14TP53TSHR | |
| SCHEMBL4551775 | 0.85 | MAPT (0.48) | MAPTMAPK14MAPK11RAF1BRAF | |
| SCHEMBL4411272 | 0.85 | MAPK14 (0.46) | NAMPTMAPTMAPK14TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |