Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371593 | 0.88 | MET (0.56) | METKDR | |
| SCHEMBL372019 | 0.86 | MET (0.57) | METKDRAXL | |
| SCHEMBL372095 | 0.84 | MET (0.68) | METKDR | |
| SCHEMBL371944 | 0.83 | MET (0.59) | METKDR | |
| SCHEMBL371680 | 0.82 | MET (0.67) | METKDR | |
| SCHEMBL29693566 | 0.82 | MET (0.67) | METKDR | |
| SCHEMBL19373118 | 0.81 | MET (0.59) | METKDR | |
| SCHEMBL371697 | 0.81 | MET (0.56) | METKDRPDGFRBPDGFRAAXL | |
| SCHEMBL409728 | 0.81 | MET (0.57) | METKDR | |
| SCHEMBL371811 | 0.80 | MET (0.64) | METKDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579473-B2 | N-(4-{[7-{[3-(diethylamino)propyl] oxy}-6-(methyloxy) quinazolin-4-yl]oxy}-3- fluorophenyl)-N'-(4- fluorophenyl) cyclopropane-1,1-dicarboxamide; for modulating protein kinase enzymatic activity for modulating cell activities such as proliferation, differentiation, programmed cell death | EXELIXIS, INC. (US) | 2009-08-25 | — | — | US | disclosed |