SCHEMBL4551817

SCHEMBL4551817

CCC(C(=O)O)(c1ccccc1)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.41
CYP3A4 P08684 1/20 0.41
RECQL P46063 1/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
ALDH1A1 P00352 3/20 0.41
MAPT P10636 2/20 0.41
MAPK1 P28482 1/20 0.41
CHRM1 P11229 4/20 0.40
CHRM2 P08172 1/20 0.40
CHRM3 P20309 1/20 0.40
PTPN1 P18031 1/20 0.39
CYP2D6 P10635 1/20 0.39
KMT2A Q03164 1/20 0.38
KIF11 P52732 1/20 0.38
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
TSHR P16473 2/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19812940 0.87 CYP2C19 (0.44) CYP1A2CYP3A4RECQLCYP2C19HIF1A
SCHEMBL3261996 0.85 CYP1A2 (0.42) CYP1A2CYP3A4RECQLCYP2C19HIF1A
SCHEMBL2699401 0.85 MAPT (0.48) CYP2C19HIF1AALDH1A1MAPTCHRM1
SCHEMBL12837474 0.82 CYP1A2 (0.42) CYP1A2CYP3A4RECQLCYP2C19HIF1A
SCHEMBL28140546 0.82 HIF1A (0.42) CYP1A2CYP2C19HIF1AALDH1A1MAPT
SCHEMBL3268588 0.82 HIF1A (0.47) CYP1A2CYP3A4RECQLCYP2C19HIF1A
SCHEMBL1666959 0.82 MAPK1 (0.47) CYP1A2CYP3A4RECQLCYP2C19HIF1A
SCHEMBL3270690 0.81 HIF1A (0.46) CYP1A2CYP3A4RECQLCYP2C19HIF1A
SCHEMBL28468416 0.81 HIF1A (0.41) CYP1A2CYP2C19HIF1AALDH1A1MAPT
SCHEMBL29010044 0.78 CYP1A2 (0.38) CYP1A2CYP2C19HIF1AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054390-A1 INDAZOLE DERIVATIVES THAT INHIBIT TRPV1 AND USES THEREOF Abbott Laboratories (US) 2009-05-06 EP disclosed
WO-2008024945-A1 INDAZOLE DERIVATIVES THAT INHIBIT TRPV1 AND USES THEREOF ABBOTT LABORATORIES (US) 2008-02-28 WO disclosed
EP-1490335-A4 BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES MERCK & CO INC (US) 2006-02-08 EP disclosed
EP-1490335-A2 BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES Merck & Co., Inc. (US) 2004-12-29 EP disclosed
WO-2003082817-A2 BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES MERCK & CO., INC. (US) 2003-10-09 WO disclosed
US-5089639-A N-CYCLOALKYLALKYLAMINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT AND THEIR SYNTHESIS INTERMEDIATES JOUVEINAL S.A. (FR) 1992-02-18 US disclosed