Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423111 | 0.91 | USP2 (0.51) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL4424650 | 0.83 | MCHR1 (0.67) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL4420094 | 0.83 | USP2 (0.60) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL12976183 | 0.79 | KDM6B (0.44) | CHRM2SMN1; SMN2ALDH1A1PDCD1CD274 | |
| SCHEMBL4418899 | 0.79 | CHRM2 (0.53) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL2263025 | 0.77 | CHRM2 (0.64) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL4419877 | 0.77 | SMN1; SMN2 (0.59) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| SCHEMBL1724753 | 0.77 | SMN1; SMN2 (0.59) | CHRM2SMN1; SMN2TMEM97SIGMAR1LMNA | |
| SCHEMBL5867347 | 0.76 | TMEM97 (0.61) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 | |
| Hydrochloric Acid SCHEMBL948529 | 0.76 | CHRM2 (0.62) | MCHR1CHRM2SMN1; SMN2TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |