Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418899 | 0.90 | CHRM2 (0.53) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 | |
| SCHEMBL10535689 | 0.84 | CHRM2 (0.58) | TMEM97SIGMAR1CHRM2SMN1; SMN2KDM4E | |
| SCHEMBL4419877 | 0.84 | SMN1; SMN2 (0.59) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL18668766 | 0.83 | CHRM2 (0.56) | TMEM97SIGMAR1CHRM2SMN1; SMN2KDM4E | |
| SCHEMBL7675039 | 0.82 | RAB9A (0.67) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 | |
| SCHEMBL4592721 | 0.82 | SIGMAR1 (0.56) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 | |
| SCHEMBL4423057 | 0.80 | SCN8A (0.51) | TMEM97SIGMAR1HRH3HRH4LMNA | |
| SCHEMBL11983494 | 0.80 | CHRM2 (0.67) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 | |
| SCHEMBL11672256 | 0.78 | CHRM2 (0.83) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 | |
| SCHEMBL19434652 | 0.78 | CHRM2 (0.91) | TMEM97SIGMAR1CHRM2SMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |