Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 2/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5612838 | 0.84 | ABCG2 (0.44) | KDM4ELMNABRD4CREBBPALDH1A1 | |
| SCHEMBL97610 | 0.80 | KDM4E (0.45) | ITGB2ICAM1ITGALADRB1KDM4E | |
| SCHEMBL7128137 | 0.80 | ITGB2 (0.44) | ITGB2ICAM1ITGALADRB1KDM4E | |
| SCHEMBL18936123 | 0.76 | BRD4 (0.33) | BRD4CREBBP | |
| SCHEMBL21160350 | 0.74 | PARP1 (0.47) | BRD4CREBBP | |
| SCHEMBL3787577 | 0.72 | ITGB2 (0.50) | ITGB2ICAM1ITGALADRB1KDM4E | |
| SCHEMBL1663066 | 0.72 | ITGB2 (0.50) | ITGB2ICAM1ITGALADRB1KDM4E | |
| SCHEMBL3072409 | 0.72 | ITGB2 (0.55) | ITGB2ICAM1ITGALADRB1KDM4E | |
| SCHEMBL18936074 | 0.69 | BRD4 (0.33) | BRD4CREBBP | |
| SCHEMBL24312061 | 0.68 | ITGB2 (0.50) | ITGB2ICAM1ITGALADRB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299354-B1 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-22 | — | — | EP | claimed |