Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 6/20 | 0.40 |
| ▸ | BRAF | P15056 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552349 | 0.93 | MAPT (0.40) | MAPK14ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4541431 | 0.92 | MAPT (0.41) | MAPK14ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4552259 | 0.91 | MAPK14 (0.48) | PLAUMAPK14RAF1BRAF | |
| SCHEMBL4551754 | 0.89 | PLAU (0.46) | PDE4BPLAUMAPK14CYP1A2DGAT1 | |
| SCHEMBL4551615 | 0.86 | PDE4B (0.45) | PDE4BPLAUMAPK14CYP1A2DGAT1 | |
| SCHEMBL4552351 | 0.84 | MAPK14 (0.44) | PLAUMAPK14ALDH1A1MAPTRAB9A | |
| SCHEMBL4541485 | 0.83 | MAPT (0.42) | PDE4BMAPK14ALDH1A1MAPTRAB9A | |
| SCHEMBL4541434 | 0.83 | MAPK14 (0.43) | MAPK14ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4543574 | 0.83 | RAB9A (0.43) | MAPK14ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4551772 | 0.82 | PDE4B (0.43) | PDE4BPLAUMAPK14CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |