Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731126 | 0.95 | CTSS (0.42) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL10274780 | 0.95 | CTSS (0.42) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL39963 | 0.94 | CTSS (0.42) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL15432825 | 0.94 | CTSS (0.42) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL46806 | 0.94 | CTSS (0.42) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL15432836 | 0.91 | CTSS (0.37) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL15420656 | 0.91 | CTSS (0.37) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL46805 | 0.90 | CTSS (0.38) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL15432826 | 0.90 | CTSS (0.38) | CTSSTAOK1TAOK3LMNAPOLB | |
| SCHEMBL18040399 | 0.90 | CTSS (0.38) | CTSSTAOK1TAOK3LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |