Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.47 |
| ▸ | GSK3B | P49841 | 7/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.47 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | NFATC1 | O95644 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CDK9 | P50750 | 4/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993571 | 0.79 | CDK5 (0.58) | GRM4CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL10338425 | 0.70 | GRM4 (1.00) | GRM4PRKACAAURKAHSP90AA1ADORA2A | |
| SCHEMBL18130895 | 0.66 | HSP90AA1 (0.60) | GRM4CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL30046927 | 0.66 | HSP90AA1 (0.60) | GRM4CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL1388378 | 0.65 | DHFR (0.54) | GRM4ADORA2A | |
| SCHEMBL316210 | 0.65 | HSP90AA1 (1.00) | GRM4GSK3BPRKACAAURKAHSP90AA1 | |
| SCHEMBL573402 | 0.64 | GSK3B (1.00) | CDK5CDK5R1GSK3BDYRK1ACLK1 | |
| SCHEMBL29488162 | 0.64 | GSK3B (1.00) | CDK5CDK5R1GSK3BDYRK1ACLK1 | |
| Hydrochloric Acid SCHEMBL17186384 | 0.64 | HSP90AA1 (0.96) | GRM4GSK3BPRKACAAURKAHSP90AA1 | |
| SCHEMBL5140478 | 0.63 | FEN1 (0.57) | GRM4CDK5CDK5R1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125803-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | Centre National de la Recherche Scientifique (FR) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008129152-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2008-10-30 | — | — | WO | disclosed |