Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 11/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HAT1 | O14929 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293948 | 0.89 | MAPK8 (0.47) | MAPTSNCAMAPK8MAPK10MAPK14 | |
| SCHEMBL4291922 | 0.80 | HPGD (0.45) | MAPTSNCAMAPK8MAPK10MAPK14 | |
| SCHEMBL13662615 | 0.80 | FYN (0.44) | MAPK8MAPK10MAPK14PARP1FYN | |
| SCHEMBL4287646 | 0.76 | SERPINE1 (0.45) | PARP1SERPINE1 | |
| SCHEMBL4294755 | 0.75 | CHEK1 (0.44) | MAPK8PARP1SERPINE1FYN | |
| SCHEMBL4287635 | 0.72 | PARP1 (0.55) | PARP1 | |
| SCHEMBL4287632 | 0.72 | CHEK1 (0.45) | MAPK8PARP1 | |
| SCHEMBL4295944 | 0.71 | SMN1; SMN2 (0.45) | MAPTMAPK10 | |
| SCHEMBL13662591 | 0.71 | RAB9A (0.45) | MAPTPARP1 | |
| SCHEMBL4298992 | 0.70 | BTK (0.49) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | MAPT 3674/4885SNCA 4066/4885MAPK8 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.