Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.75 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553613 | 0.91 | EGLN1 (0.76) | EGLN1EGLN2EGLN3CNR2HSD17B13 | |
| SCHEMBL13437410 | 0.86 | EGLN1 (0.69) | EGLN1EGLN2EGLN3CNR2HSD17B13 | |
| SCHEMBL3512354 | 0.86 | EGLN1 (1.00) | EGLN1EGLN2EGLN3CNR2 | |
| SCHEMBL13437414 | 0.82 | EGLN1 (0.81) | EGLN1EGLN2EGLN3CNR2HSD17B13 | |
| SCHEMBL7833529 | 0.75 | EGLN1 (0.56) | EGLN1CNR2CNR1L3MBTL1 | |
| SCHEMBL3518609 | 0.72 | EGLN1 (0.52) | EGLN1EGLN2EGLN3CNR2HSD17B13 | |
| SCHEMBL7833351 | 0.72 | EGLN1 (0.54) | EGLN1CNR2LMNAL3MBTL1 | |
| SCHEMBL3513806 | 0.71 | EGLN1 (0.51) | EGLN1EGLN2EGLN3CNR2LMNA | |
| SCHEMBL3514759 | 0.70 | EGLN1 (0.75) | EGLN1EGLN2EGLN3CNR2CNR1 | |
| SCHEMBL4553700 | 0.69 | EGLN1 (0.49) | EGLN1EGLN2EGLN3CNR2HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136810-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | Merck & Co., Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008130527-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | MERCK & CO., INC. (US) | 2008-10-30 | — | — | WO | disclosed |