Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553700 | 0.84 | EGLN1 (0.49) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL3518628 | 0.81 | EGLN1 (0.44) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL3513806 | 0.80 | EGLN1 (0.51) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL3518609 | 0.79 | EGLN1 (0.52) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL3514759 | 0.79 | EGLN1 (0.75) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL3514775 | 0.77 | EGLN1 (0.56) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL27793219 | 0.77 | EGLN1 (0.56) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL3512344 | 0.76 | TP53 (0.41) | EGLN1CNR2CNR1PTGDR2EGLN2 | |
| SCHEMBL13437408 | 0.76 | EGLN1 (0.61) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL1941561 | 0.72 | PTGDR2 (0.76) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136810-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | Merck & Co., Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008130527-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | MERCK & CO., INC. (US) | 2008-10-30 | — | — | WO | disclosed |