Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 6/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553698 | 0.81 | EGLN1 (0.47) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL4553700 | 0.76 | EGLN1 (0.49) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL3513806 | 0.76 | EGLN1 (0.51) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL3518609 | 0.75 | EGLN1 (0.52) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL3514759 | 0.73 | EGLN1 (0.75) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL13437408 | 0.72 | EGLN1 (0.61) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL3514775 | 0.71 | EGLN1 (0.56) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL27793219 | 0.71 | EGLN1 (0.56) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL3512344 | 0.69 | TP53 (0.41) | EGLN1CNR2CNR1EGLN2EGLN3 | |
| SCHEMBL4553615 | 0.69 | EGLN1 (0.75) | EGLN1CNR2CNR1EGLN2EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | HIF1AN, HIF1A, EGLN2 | EGLN1 5/4885CNR2 2485/4885CNR1 1567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.