Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 15/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325750 | 0.85 | PSEN1 (0.42) | KIF11KCNMA1PSEN1PSEN2APH1B | |
| SCHEMBL3579491 | 0.84 | PSEN1 (0.47) | KIF11KCNMA1PSEN1PSEN2APH1B | |
| SCHEMBL13298692 | 0.83 | KIF11 (0.41) | KIF11TDP2 | |
| SCHEMBL3330308 | 0.83 | DDR1 (0.38) | KIF11 | |
| SCHEMBL2890988 | 0.80 | HDAC2 (0.45) | KIF11 | |
| SCHEMBL3580763 | 0.78 | PSEN1 (0.45) | KCNMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3574142 | 0.77 | PSEN1 (0.44) | KCNMA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3577053 | 0.77 | KDR (0.51) | — | |
| SCHEMBL3329979 | 0.76 | KIF11 (0.41) | KIF11TDP2 | |
| SCHEMBL3584713 | 0.76 | MTOR (0.41) | KIF11PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121640-A1 | NOVEL SEMICARBAZIDE AND CARBONYLHYDRAZIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NeuroSearch AS (DK) | 2009-11-25 | — | — | EP | claimed |
| WO-2008087177-A1 | NOVEL SEMICARBAZIDE AND CARBONYLHYDRAZIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-07-24 | — | — | WO | claimed |