Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305616 | 0.94 | KDM4E (0.64) | KDM4EALDH1A1MAPTPKMUSP2 | |
| Hydrochloric Acid SCHEMBL4652172 | 0.92 | KDM4E (0.62) | KDM4EALDH1A1MAPTPKMUSP2 | |
| SCHEMBL20193318 | 0.85 | KDM4E (0.65) | KDM4EALDH1A1MAPTUSP2NPC1 | |
| SCHEMBL22442320 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1MAPTPKMUSP2 | |
| SCHEMBL63652 | 0.81 | HPGD (0.49) | KDM4EALDH1A1MAPTPKMNPC1 | |
| SCHEMBL14417582 | 0.81 | MAPT (0.64) | KDM4EALDH1A1MAPTPKMHDAC4 | |
| SCHEMBL14161817 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1MAPTPKMHDAC4 | |
| SCHEMBL419882 | 0.80 | ALDH1A1 (0.69) | KDM4EALDH1A1MAPTPKMUSP2 | |
| SCHEMBL23610369 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1MAPTUSP2NPC1 | |
| SCHEMBL17737082 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1MAPTUSP2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |