Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | MST1R | Q04912 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554753 | 0.84 | HTR2A (0.35) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL27772671 | 0.82 | MAPK8 (0.36) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL4554653 | 0.77 | NPY5R (0.38) | NPY5RFPR2PROKR1PHGDHPIM1 | |
| SCHEMBL4554326 | 0.75 | MAPK8 (0.36) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL4554327 | 0.75 | MAPK8 (0.38) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL4553497 | 0.74 | MAPK8 (0.38) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL4553742 | 0.73 | MAPK8 (0.37) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL4554134 | 0.73 | PHGDH (0.34) | HTR2AHTR2CMAPK8MAPK9MAPK10 | |
| SCHEMBL964783 | 0.73 | HTR2A (0.35) | NPY5RHTR2AHTR2CMAPK8MAPK9 | |
| SCHEMBL965282 | 0.72 | HTR2A (0.39) | HTR2AHTR2CMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | claimed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | claimed |
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |