Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554742 | 0.83 | MAPK8 (0.31) | PHGDHCRHR1MAPK8MAPK9MAPK10 | |
| SCHEMBL4554753 | 0.81 | HTR2A (0.35) | PHGDHCRHR1MAPK8MAPK9MAPK10 | |
| SCHEMBL27772671 | 0.79 | MAPK8 (0.36) | PHGDHMAPK8MAPK9MAPK10SLC6A2 | |
| SCHEMBL4554132 | 0.78 | MAPK8 (0.37) | PHGDHCRHR1MAPK8MAPK9MAPK10 | |
| SCHEMBL961662 | 0.76 | KMT2A (0.41) | PHGDHMAPK8MAPK9MAPK10SLC6A2 | |
| SCHEMBL962579 | 0.76 | KMT2A (0.41) | PHGDHCRHR1MAPK8MAPK9MAPK10 | |
| SCHEMBL4553763 | 0.75 | ADA (0.31) | CRHR1 | |
| SCHEMBL4554326 | 0.74 | MAPK8 (0.36) | PHGDHMAPK8MAPK9MAPK10SLC6A2 | |
| SCHEMBL4555123 | 0.74 | MAPK8 (0.33) | PHGDHCRHR1MAPK8MAPK9MAPK10 | |
| SCHEMBL4553736 | 0.74 | HTR2A (0.34) | CRHR1SLC6A2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |