Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 8/20 | 0.32 |
| ▸ | PIM1 | P11309 | 4/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11907357 | 0.87 | PIM2 (0.44) | PIM2PIM3PIM1 | |
| SCHEMBL4555400 | 0.82 | PIM2 (0.34) | PIM2PIM3PIM1 | |
| SCHEMBL4554934 | 0.80 | BTK (0.42) | PIM2PIM3PIM1USP30 | |
| SCHEMBL1710280 | 0.79 | MAPT (0.36) | PIM2PIM3PIM1 | |
| SCHEMBL11898914 | 0.79 | MAPT (0.36) | PIM2PIM3PIM1 | |
| SCHEMBL4433671 | 0.79 | MAPT (0.36) | PIM2PIM3PIM1 | |
| SCHEMBL11907424 | 0.76 | PIM2 (0.47) | PIM2PIM3PIM1 | |
| SCHEMBL11906999 | 0.76 | PIM2 (0.47) | PIM2PIM3PIM1 | |
| SCHEMBL3434075 | 0.74 | KDM4E (0.34) | PIM2PIM3PIM1USP30 | |
| SCHEMBL4438265 | 0.72 | PIM2 (0.47) | PIM2PIM3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |