Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212552 | 0.96 | KDR (0.50) | KDRENPP3GAAFLT1ALDH1A1 | |
| SCHEMBL2976974 | 0.89 | ENPP3 (0.47) | KDRENPP3GAAALDH1A1HPGD | |
| SCHEMBL15663807 | 0.87 | KDR (0.53) | KDRENPP3GAAFLT1ALDH1A1 | |
| SCHEMBL15663721 | 0.85 | KDR (0.42) | KDRENPP3GAAFLT1ALDH1A1 | |
| SCHEMBL15663574 | 0.84 | ENPP3 (0.44) | KDRENPP3GAAALDH1A1MAPT | |
| SCHEMBL15663740 | 0.84 | KDR (0.44) | KDRENPP3GAAHPGDMAPT | |
| SCHEMBL3699428 | 0.83 | KDR (0.46) | KDRENPP3GAAFLT1ALDH1A1 | |
| SCHEMBL15663473 | 0.83 | KDR (0.51) | KDRENPP3GAAFLT1ALDH1A1 | |
| SCHEMBL15663371 | 0.82 | KDR (0.50) | KDRENPP3GAAALDH1A1HPGD | |
| SCHEMBL3711392 | 0.81 | KDR (0.51) | KDRENPP3GAAFLT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |