Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 16/20 | 0.75 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073973 | 0.86 | EPHX2 (1.00) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL3069069 | 0.79 | EPHX2 (0.69) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL3085328 | 0.79 | EPHX2 (0.47) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL28221127 | 0.78 | EPHX2 (0.75) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL10050571 | 0.78 | EPHX2 (0.75) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL3071635 | 0.78 | EPHX1 (0.68) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL1605416 | 0.77 | EPHX2 (0.67) | EPHX2EPHX1 | |
| SCHEMBL29416853 | 0.74 | EPHX2 (0.72) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL8391320 | 0.73 | EPHX2 (0.67) | EPHX2EPHX1ALDH1A1 | |
| SCHEMBL19757637 | 0.73 | EPHX2 (0.67) | EPHX2EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214680-A1 | ADAMANTANE COMPOUNDS | THE UNIVERSITY OF SYDNEY (AU) | 2017-12-21 | — | — | WO | disclosed |
| WO-2013090929-A1 | AMINO QUINOLINE DERIVATIVES INHIBITORS OF HCV | GILEAD SCIENCES, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
| EP-2240175-B1 | COMPOUNDS WITH MDR1-INVERSE ACTIVITY | US GOV HEALTH & HUMAN SERV (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2012033601-A1 | THIOSEMICARBAZONES WITH MDR1 - INVERSE ACTIVITY | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2012-03-15 | — | — | WO | disclosed |
| US-20100316655-A1 | COMPOUNDS WITH MDR1-INVERSE ACTIVITY | INSTITUTE OF ENZYMOLOGY, BIOLOGICAL RESEARCH CENTER, HUNGARIAN ACADEMY OF SCIENCES (HU) | 2010-12-16 | — | — | US | disclosed |
| EP-2240175-A2 | COMPOUNDS WITH MDR1-INVERSE ACTIVITY | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009102433-A2 | COMPOUNDS WITH MDR1-INVERSE ACTIVITY | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-08-20 | — | — | WO | disclosed |
| US-5281597-A | Administering thiosemicarbazone or salt or suspension thereof to mammals | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1994-01-25 | — | — | US | disclosed |
| US-4871737-A | 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4777166-A | DIOL VEHICLE; HERPES VIRUS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1988-10-11 | — | — | US | disclosed |
| US-4739069-A | TREATMENT OF GONORRHEA, MALARIA, INFECTIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1988-04-19 | — | — | US | disclosed |
| US-4665173-A | ANTIMALARIAL, ANTILEUKEMIC | UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 1987-05-12 | — | — | US | disclosed |
| US-4657903-A | Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4596798-A | Herpes virus | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-06-24 | — | — | US | disclosed |
| US-4493930-A | BACTERICIDES, ANTIMALARIA, AND ANTIGONORRHEA AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1985-01-15 | — | — | US | disclosed |
| US-4447427-A | PARTICULARLY GONORRHEA OR MALARIA | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4401670-A | Method for treating gonorrhea infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1983-08-30 | — | — | US | disclosed |
| US-4385055-A | 2-Acetyl-and 2-propionylpyridine thiosemicarbazones as antimalarials | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1983-05-24 | — | — | US | disclosed |
| US-4317776-A | BACTERICIDES, ANTIMALARIAL, TREATMENT OF GONORRHEA | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1982-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100316655-A1 | COMPOUNDS WITH MDR1-INVERSE ACTIVITY | ABCC1, ABCB1, ABCC2 | EPHX2 3912/4885EPHX1 3395/4885ALDH1A1 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.