Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL961700 | 0.83 | IRAK4 (0.33) | IRAK4MCHR1 | |
| SCHEMBL966734 | 0.81 | IRAK4 (0.35) | IRAK4MCHR1HPGDHTTHSD17B10 | |
| SCHEMBL4554378 | 0.80 | IRAK4 (0.34) | IRAK4HPGDHTTHSD17B10 | |
| SCHEMBL5127447 | 0.79 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL962375 | 0.76 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL962380 | 0.76 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL962378 | 0.75 | IRAK4 (0.33) | IRAK4 | |
| SCHEMBL963693 | 0.75 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL962130 | 0.74 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL962959 | 0.69 | HPGD (0.32) | IRAK4HPGDHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |