Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963384 | 0.83 | IRAK4 (0.33) | IRAK4LMNAALDH1A1 | |
| SCHEMBL962809 | 0.80 | ADAMTS5 (0.35) | IRAK4L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4554212 | 0.80 | IRAK4 (0.34) | IRAK4HPGDHTTHSD17B10 | |
| SCHEMBL4570524 | 0.79 | IRAK4 (0.35) | IRAK4L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4570113 | 0.78 | IRAK4 (0.33) | IRAK4L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27772780 | 0.77 | POLB (0.36) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL965261 | 0.76 | ADAMTS5 (0.33) | IRAK4MEN1KMT2AHPGDHTT | |
| SCHEMBL965265 | 0.76 | ADAMTS5 (0.33) | IRAK4MEN1KMT2AHPGDHTT | |
| SCHEMBL965263 | 0.75 | IRAK4 (0.33) | IRAK4 | |
| SCHEMBL963027 | 0.74 | IRAK4 (0.33) | IRAK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |