Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134427 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2QDPRESR1HSD17B1HSD17B10 | |
| SCHEMBL578932 | 0.70 | GAA (0.35) | GAA | |
| SCHEMBL9717101 | 0.68 | GAA (0.34) | GAA | |
| Iodide SCHEMBL6292630 | 0.68 | GAA (0.34) | GAA | |
| Hydrochloric Acid SCHEMBL11333509 | 0.68 | GAA (0.34) | GAA | |
| SCHEMBL5392280 | 0.65 | — | — | |
| Acetic Acid SCHEMBL984620 | 0.65 | TSHR (0.39) | GAA | |
| SCHEMBL14008437 | 0.62 | GAA (0.36) | SMN1; SMN2GAA | |
| SCHEMBL15071294 | 0.61 | TSHR (0.35) | — | |
| SCHEMBL1515973 | 0.61 | NPC1 (0.70) | SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |