Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2102560 | 1.00 | CENPE (0.68) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2104936 | 0.93 | CENPE (0.71) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2104390 | 0.92 | CENPE (0.65) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL4761956 | 0.92 | CENPE (0.65) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL3462266 | 0.92 | CENPE (0.80) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2104176 | 0.92 | CENPE (0.80) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2100836 | 0.91 | CENPE (0.69) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2617335 | 0.91 | CENPE (0.69) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2104360 | 0.91 | CENPE (0.78) | CENPEALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL2104839 | 0.90 | CENPE (0.69) | CENPEALDH1A1KDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618981-B2 | to treat cellular proliferative diseases, hyperplasias, solid tumor, cardiac hypertrophy, immune disorders and inflammation; modulators of one or more mitotic kinesins; N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide | CYTOKINETICS, INC. (US) | 2009-11-17 | — | — | US | disclosed |