Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487075 | 0.81 | GPR119 (0.72) | GPR119CKS1BSKP1SKP2 | |
| SCHEMBL14138630 | 0.80 | GPR119 (0.45) | GPR119HCRTR1HCRTR2KDM4E | |
| SCHEMBL14138631 | 0.80 | GPR119 (0.49) | GPR119KCNH2HCRTR1HCRTR2KDM4E | |
| SCHEMBL3621655 | 0.77 | GPR119 (0.56) | GPR119KCNH2KDM4E | |
| SCHEMBL988306 | 0.76 | KCNH2 (0.50) | GPR119KCNH2KDM4E | |
| SCHEMBL9885064 | 0.74 | KCNH2 (0.51) | GPR119KCNH2KDM4E | |
| SCHEMBL25215605 | 0.73 | ACKR3 (0.38) | GPR119KDM4ECKS1BSKP1SKP2 | |
| SCHEMBL20804678 | 0.73 | CKS1B (0.54) | CKS1BSKP1SKP2 | |
| SCHEMBL15219250 | 0.73 | KCNH2 (0.50) | GPR119KCNH2CKS1BSKP1SKP2 | |
| SCHEMBL10316058 | 0.72 | GPR119 (0.66) | GPR119KCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |