Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554648 | 0.92 | HDAC3 (0.35) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962968 | 0.86 | MTNR1A (0.34) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962971 | 0.86 | MTNR1A (0.34) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL967860 | 0.82 | MTNR1A (0.37) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL967858 | 0.82 | MTNR1A (0.37) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962309 | 0.79 | MTNR1A (0.35) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962308 | 0.79 | MTNR1A (0.35) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962821 | 0.78 | HDAC3 (0.35) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962820 | 0.78 | HDAC3 (0.35) | MTNR1AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL962754 | 0.76 | CNR1 (0.35) | MTNR1AHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |