Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31445919 | 1.00 | TNKS2 (0.35) | TNKS2NAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL25175695 | 0.86 | PARP1 (0.33) | TNKS2NAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL31691814 | 0.86 | PARP1 (0.33) | TNKS2NAPRTL3MBTL1LMNAP4HTM | |
| SCHEMBL29165232 | 0.79 | POLB (0.42) | TNKS2L3MBTL1LMNATDP1ALDH1A1 | |
| SCHEMBL24735437 | 0.76 | GSK3B (0.33) | TNKS2GSK3B | |
| SCHEMBL19142929 | 0.73 | GSK3B (0.40) | TNKS2GSK3B | |
| Hydrochloric Acid SCHEMBL7435031 | 0.71 | MAPT (0.39) | KDM4ETDP1NPC1ALDH1A1CYP3A4 | |
| SCHEMBL28616267 | 0.69 | GSK3B (0.31) | TNKS2GSK3B | |
| SCHEMBL29763588 | 0.69 | TNKS2 (0.34) | TNKS2ALDH1A1KMT2A | |
| SCHEMBL9535536 | 0.68 | KDM4E (0.33) | TNKS2L3MBTL1KDM4EGSK3BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774817-A1 | BCL6 INHIBITORS | Cancer Research Technology Limited (GB) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019197842-A1 | BCL6 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2019-10-17 | — | — | WO | disclosed |
| EP-2136810-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | Merck & Co., Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008130527-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | MERCK & CO., INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| CN-1148369-C | 1,8-naphthyridine derivatives | ֮����ҩ��ʽ���� | 2004-05-05 | — | — | CN | disclosed |
| CN-1382141-A | 1,8-naphthyridine derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 2002-11-27 | — | — | CN | disclosed |
| EP-0784622-A1 | NAPHTHYRIDINONE DERIVATIVES | Knoll AG (DE) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996011199-A1 | NAPHTHYRIDINONE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-04-18 | — | — | WO | disclosed |
| WO-1995007909-A1 | ALKYL-1-ALKYL-4-HYDROXY-2-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLATES AS ANTI-RHEUMATIC AGENTS | KNOLL AG (DE) | 1995-03-23 | — | — | WO | disclosed |