Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | AGER | Q15109 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603455 | 0.77 | EGFR (0.42) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL4554798 | 0.68 | TNKS2 (0.35) | KDM4EMAPTTNKS2ALDH1A1NPC1 | |
| SCHEMBL31445919 | 0.68 | TNKS2 (0.35) | KDM4EMAPTTNKS2ALDH1A1NPC1 | |
| SCHEMBL13858832 | 0.67 | GSK3B (0.36) | TNKS2GSK3B | |
| SCHEMBL21500733 | 0.66 | NPC1 (0.43) | KDM4EMAPTCYP1A2TNKS2NPC1 | |
| SCHEMBL25385846 | 0.64 | KDM4E (0.36) | KDM4EMAPTCYP1A2TNKS2ALDH1A1 | |
| SCHEMBL31691814 | 0.64 | PARP1 (0.33) | MAPTTNKS2NPC1GSK3BL3MBTL1 | |
| SCHEMBL25175695 | 0.64 | PARP1 (0.33) | MAPTTNKS2NPC1GSK3BL3MBTL1 | |
| SCHEMBL26124470 | 0.61 | GSK3B (0.36) | KDM4ETNKS2HSD17B10NPC1GSK3B | |
| SCHEMBL27773502 | 0.59 | GSK3B (0.34) | TNKS2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568540-A1 | 2,4-DIOXO-PYRIDO 2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1993-11-10 | — | — | EP | disclosed |
| WO-1992012979-A1 | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1992-08-06 | — | — | WO | disclosed |