Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.68 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13644396 | 1.00 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL13162047 | 1.00 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2104812 | 1.00 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2103746 | 1.00 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL13161858 | 0.94 | CENPE (0.66) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL13161822 | 0.94 | CENPE (0.66) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3462504 | 0.94 | CENPE (0.66) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL13161647 | 0.94 | CENPE (0.71) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2103889 | 0.94 | CENPE (0.71) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3460971 | 0.93 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618981-B2 | to treat cellular proliferative diseases, hyperplasias, solid tumor, cardiac hypertrophy, immune disorders and inflammation; modulators of one or more mitotic kinesins; N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide | CYTOKINETICS, INC. (US) | 2009-11-17 | — | — | US | disclosed |