SCHEMBL4555149

SCHEMBL4555149

CCc1cn(S(=O)(=O)C2=CN(C)CCO2)c2cc(N3CCNCC3)ccc12

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 18/20 0.45
KHK P50053 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5095090 0.80 HTR6 (0.55) HTR6
SCHEMBL5097223 0.79 HTR6 (0.52) HTR6
SCHEMBL5097149 0.73 RXFP1 (0.50) HTR6
SCHEMBL5103909 0.72 HTR6 (0.49) HTR6KHK
SCHEMBL5103912 0.72 HTR6 (0.49) HTR6KHK
SCHEMBL5097439 0.69 HTR6 (0.51) HTR6KHK
SCHEMBL5097433 0.69 HTR6 (0.51) HTR6KHK
SCHEMBL5097429 0.68 HTR6 (0.54) HTR6
SCHEMBL5097154 0.67 HTR6 (0.51) HTR6
SCHEMBL14100641 0.64 KHK (0.48) HTR6KHK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121603-A2 6' SUBSTITUTED INDOLE AND INDAZOLE DERIVATIVES HAVING 5-HT6 RECEPTOR AFFINITY Memory Pharmaceuticals Corporation (US) 2009-11-25 EP claimed
WO-2008101247-A2 6 ' SUBSTITUTED INDOLE AND INDAZOLE DERIVATIVES HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2008-08-21 WO claimed