Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.70 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27226900 | 0.88 | GPR119 (0.54) | GPR119RIPK1CHEK1CHEK2KMO | |
| SCHEMBL25260940 | 0.83 | GPR119 (0.58) | GPR119RIPK1CHEK1CHEK2KMO | |
| SCHEMBL30339666 | 0.83 | GPR119 (0.58) | GPR119RIPK1CHEK1CHEK2KMO | |
| SCHEMBL3486381 | 0.83 | GPR119 (1.00) | GPR119 | |
| SCHEMBL4555482 | 0.80 | GPR119 (0.46) | GPR119KMOCHRM4LOXL2 | |
| SCHEMBL14138631 | 0.80 | GPR119 (0.49) | GPR119KCNH2KMOCHRM4LOXL2 | |
| SCHEMBL3617657 | 0.80 | GPR119 (0.58) | GPR119RIPK1KCNH2CHEK1CHEK2 | |
| SCHEMBL3486651 | 0.79 | GPR119 (0.57) | GPR119RIPK1KCNH2CHEK1CHEK2 | |
| SCHEMBL20337973 | 0.78 | GPR119 (0.53) | GPR119RIPK1CHEK1LOXL2 | |
| SCHEMBL10316047 | 0.77 | GPR119 (0.55) | GPR119RIPK1KCNH2CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |