Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206562 | 0.89 | — | — | |
| SCHEMBL29838521 | 0.89 | — | — | |
| SCHEMBL206561 | 0.89 | — | — | |
| SCHEMBL8989292 | 0.81 | — | — | |
| SCHEMBL8989288 | 0.81 | — | — | |
| Bicarbonate SCHEMBL10708950 | 0.78 | ALDH1A1 (0.40) | ALDH1A1LMNATSHRABCC4MAPT | |
| SCHEMBL8980049 | 0.77 | — | — | |
| SCHEMBL13569511 | 0.77 | — | — | |
| SCHEMBL8980050 | 0.77 | — | — | |
| SCHEMBL3258860 | 0.77 | ALDH1A1 (0.39) | ALDH1A1LMNAABCC4MAPTFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111954952-A | Nonaqueous electrolyte secondary battery | 日产自动车株式会社 | 2020-11-17 | — | — | CN | disclosed |
| EP-2120855-A2 | USE OF CHROMAN-4-ON-DERIVATIVES | Merck Patent GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008113450-A2 | USE OF CHROMAN-4-ON-DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | WO | disclosed |