Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 20/20 | 0.50 |
| ▸ | PIM1 | P11309 | 17/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 17/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434950 | 0.89 | PIM2 (0.46) | PIM2PIM1PIM3 | |
| SCHEMBL4555208 | 0.84 | PIM2 (0.38) | PIM2PIM1PIM3 | |
| SCHEMBL4437161 | 0.79 | PIM2 (0.44) | PIM2PIM1PIM3 | |
| SCHEMBL11909095 | 0.73 | PIM2 (0.83) | PIM2PIM1PIM3 | |
| SCHEMBL16004176 | 0.71 | PIM2 (0.51) | PIM2PIM1PIM3 | |
| SCHEMBL12077496 | 0.70 | PIM3 (0.63) | PIM2PIM1PIM3 | |
| SCHEMBL11906299 | 0.69 | PIM2 (0.71) | PIM2PIM1PIM3 | |
| SCHEMBL11984296 | 0.69 | PIM2 (0.62) | PIM2PIM1PIM3 | |
| SCHEMBL11984874 | 0.68 | PIM2 (0.62) | PIM2PIM1PIM3 | |
| SCHEMBL4444624 | 0.67 | PIM2 (0.44) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |