Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20558345 | 0.83 | GAA (0.67) | GAAALDH1A1PTGS1LMNACSF1R | |
| SCHEMBL4993846 | 0.81 | ALDH1A1 (0.67) | GAAALDH1A1PTGS1LMNACSF1R | |
| SCHEMBL21870341 | 0.79 | GAA (1.00) | GAAALDH1A1PTGS1LMNACSF1R | |
| SCHEMBL27530863 | 0.78 | GAA (0.65) | GAAALDH1A1PTGS1LMNACSF1R | |
| SCHEMBL4997367 | 0.77 | PTGS1 (0.61) | GAAPTGS1KITMEN1RAB9A | |
| SCHEMBL19233515 | 0.77 | PTGS1 (0.68) | GAAALDH1A1PTGS1LMNACSF1R | |
| Hydrochloric Acid SCHEMBL5004557 | 0.76 | PTGS1 (0.68) | GAAPTGS1LMNACSF1RKIT | |
| SCHEMBL1273833 | 0.76 | GAA (0.70) | GAAALDH1A1LMNACSF1RKIT | |
| SCHEMBL4749894 | 0.75 | PTGS1 (0.65) | GAAALDH1A1PTGS1LMNACSF1R | |
| SCHEMBL27720492 | 0.75 | CSF1R (0.55) | GAAPTGS1CSF1RKITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121692-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008079965-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |