Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL28251608 | 0.92 | IDO1 (0.85) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL455344 | 0.89 | IDO1 (0.78) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL10099725 | 0.86 | GAA (0.83) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL469849 | 0.82 | NOX1 (0.84) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL7658710 | 0.81 | MEN1 (0.68) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL1642748 | 0.80 | IDO1 (0.67) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL455323 | 0.80 | GAA (0.74) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL9036250 | 0.80 | IDO1 (0.64) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL6302052 | 0.78 | GAA (0.64) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL10710275 | 0.78 | NOX1 (0.85) | IDO1MAPTGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102786464-B | Phthiobuzonum derivative and its production and use | BEIJING UNION PHARMACEUTICAL FACTORY (CN) | 2016-05-11 | — | — | CN | claimed |
| CN-102786464-A | Ftibamzone derivative and preparation method and application thereof | BEIJING UNION PHARMACEUTICAL FACTORY | 2012-11-21 | — | — | CN | claimed |
| CN-1990470-B | Phthiobuzonum derivative, its manufacturing process, pharmaceutical combination and uses thereof | BEIJING XIEHE PHARMACEUTICAL FACTORY | 2011-04-20 | — | — | CN | claimed |
| CN-1671717-A | Azole derivatives as antifungal agents | RANBAXY LAB LTD (IN) | 2005-09-21 | — | — | CN | claimed |
| US-12421207-B2 | Pyrimidinedione-based compounds as AXL, c-MET, and Mer inhibitors and methods of use thereof | CMG PHARMACEUTICAL CO., LTD. (KR) | 2025-09-23 | — | — | US | disclosed |
| US-20250171426-A1 | PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG PHARMACEUTICAL CO., LTD. (KR) | 2025-05-29 | — | — | US | disclosed |
| WO-2025046420-A1 | COMPOUND TARGETING EGR-1 AND USE THEREOF FOR TREATMENT OF ATOPIC DERMATITIS | 주식회사 아제라메디 | 2025-03-06 | — | — | WO | disclosed |
| EP-4479397-A1 | PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG Pharmaceutical Co., Ltd. (KR) | 2024-12-25 | — | — | EP | disclosed |
| US-20240174666-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2024-05-30 | — | — | US | disclosed |
| CN-114634502-B | 3-Aryl substituted thiazolidine-4-ketone-2-methylene hydrazono methylene-1H-indole derivative and preparation method thereof | 复旦大学 | 2024-05-24 | — | — | CN | disclosed |
| EP-3843850-B1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC (US) | 2023-11-15 | — | — | EP | disclosed |
| US-20230348423-A1 | PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | CMG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-02 | — | — | US | disclosed |
| EP-1697328-A1 | PYRAZOLINOLS USED AS PESTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005092873-A2 | THIADIAZOLES FOR TREATMENT OF CANCER OR NEUROLOGICAL DISEASE | UNIWERSYTET MARII CURIE SKLODOWSKIEJ (PL) | 2005-10-06 | — | — | WO | disclosed |
| CN-1671717-A | Azole derivatives as antifungal agents | RANBAXY LAB LTD (IN) | 2005-09-21 | — | — | CN | disclosed |
| WO-2005058838-A1 | PYRAZOLINOLS USED AS PESTICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005051381-A1 | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) | BIOVITRUM AB (SE) | 2005-06-09 | — | — | WO | disclosed |
| US-5571843-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1996-11-05 | — | — | US | disclosed |
| EP-0566445-A1 | Derivatives of indane 1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020045-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR THE PREPARATION OF SAME AND THEIR APPLICATION AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171426-A1 | PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | MERTK, AXL, RET | IDO1 3652/4885MAPT 2509/4885KDM4E 1440/4885 |
| US-20240174666-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | RET, MERTK, MET | IDO1 2711/4885MAPT 833/4885KDM4E 951/4885 |
| US-12421207-B2 | Pyrimidinedione-based compounds as AXL, c-MET, and Mer inhibitors and methods of use thereof | MERTK, AXL, MET | IDO1 3934/4885MAPT 2741/4885KDM4E 1703/4885 |
| US-20230348423-A1 | PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF | MERTK, AXL, MET | IDO1 3934/4885MAPT 2741/4885KDM4E 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.