Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26010794 | 1.00 | L3MBTL1 (0.67) | L3MBTL1TSHRRECQLKMT2ALMNA | |
| SCHEMBL4228483 | 0.83 | L3MBTL1 (0.63) | L3MBTL1TSHRKMT2ALMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL1348323 | 0.81 | L3MBTL1 (0.66) | L3MBTL1TSHRKMT2ALMNAMAPK1 | |
| SCHEMBL29512604 | 0.80 | KMT2A (0.64) | L3MBTL1TSHRRECQLKMT2ALMNA | |
| SCHEMBL12793360 | 0.79 | KMT2A (0.68) | L3MBTL1TSHRRECQLKMT2ALMNA | |
| SCHEMBL13341708 | 0.79 | L3MBTL1 (0.51) | L3MBTL1TSHRRECQLKMT2ALMNA | |
| SCHEMBL2976598 | 0.79 | TSHR (1.00) | TSHRRECQLKMT2ALMNAMAPK1 | |
| SCHEMBL18711914 | 0.78 | L3MBTL1 (0.61) | L3MBTL1TSHRKMT2ALMNAMAPK1 | |
| SCHEMBL621187 | 0.76 | TSHR (0.96) | L3MBTL1TSHRRECQLKMT2ALMNA | |
| SCHEMBL29512737 | 0.76 | KMT2A (0.59) | L3MBTL1TSHRRECQLKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134714-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | Biovitrum AB (publ) (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008110598-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | BIOVITRUM AB (PUBL) (SE) | 2008-09-18 | — | — | WO | disclosed |