Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553952 | 0.85 | SMN1; SMN2 (0.38) | PIK3CAMTORSMN1; SMN2PIK3CBPIK3CG | |
| SCHEMBL5252377 | 0.82 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1089140 | 0.76 | PIK3CA (0.42) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL189736 | 0.76 | PIK3CA (0.53) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL1181831 | 0.75 | PIK3CA (0.43) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL4555688 | 0.75 | PIK3CA (0.41) | PIK3CAPIK3R1MTORPIK3CDSMN1; SMN2 | |
| SCHEMBL5251923 | 0.75 | PIK3CA (0.41) | PIK3CAPIK3R1MTORPIK3CDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30151144 | 0.75 | PIK3CA (0.53) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL1182606 | 0.75 | PIK3CA (0.53) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL190175 | 0.74 | PIK3CA (0.39) | PIK3CAPIK3R1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |