Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555746 | 0.85 | PIK3CA (0.42) | SMN1; SMN2PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL190250 | 0.76 | PIK3CA (0.50) | SMN1; SMN2PIK3CAPIK3CB | |
| SCHEMBL13640276 | 0.73 | PIK3CA (0.52) | SMN1; SMN2HRH3PIK3CAPIK3CB | |
| SCHEMBL4440313 | 0.73 | PIK3CA (0.43) | SMN1; SMN2HRH3PIK3CAPIK3CBMTOR | |
| SCHEMBL4434053 | 0.73 | PIK3CA (0.50) | SMN1; SMN2HRH3PIK3CAPIK3CBMTOR | |
| SCHEMBL1182397 | 0.71 | HRH3 (0.56) | HRH3PIK3CAPIK3CB | |
| SCHEMBL4068550 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2HRH3PIK3CAPIK3CBMTOR | |
| SCHEMBL5252377 | 0.70 | PIK3CA (0.61) | PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL1181231 | 0.70 | PIK3CA (0.50) | SMN1; SMN2HRH3PIK3CAPIK3CB | |
| SCHEMBL466308 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2HRH3PIK3CAPIK3CBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |