Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4177944 | 1.00 | KDM4E (0.44) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1787083 | 0.88 | ALDH1A1 (0.48) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4174879 | 0.87 | ALDH1A1 (0.47) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3932510 | 0.87 | ALDH1A1 (0.47) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4751869 | 0.85 | ALDH1A1 (0.43) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4189521 | 0.85 | ALDH1A1 (0.46) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4191981 | 0.81 | ALDH1A1 (0.52) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4754155 | 0.80 | ALDH1A1 (0.52) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL13984358 | 0.78 | HSP90AA1 (0.43) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1953789 | 0.78 | ALDH1A1 (0.46) | KDM4ECYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069355-A1 | NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008010765-A1 | NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2008-01-24 | — | — | WO | disclosed |