Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.60 |
| ▸ | MGLL | Q99685 | 9/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605978 | 0.92 | GPR119 (0.69) | GPR119MGLLALKEPHX2 | |
| SCHEMBL15050771 | 0.86 | GPR119 (0.64) | GPR119MGLLALKEPHX2 | |
| SCHEMBL21887547 | 0.86 | GPR119 (0.61) | GPR119MGLLALKEPHX2 | |
| SCHEMBL21825159 | 0.86 | GPR119 (0.61) | GPR119MGLLALKEPHX2 | |
| SCHEMBL3605088 | 0.85 | EPHX2 (0.59) | GPR119MGLLEPHX2 | |
| SCHEMBL30324507 | 0.81 | GPR119 (0.54) | GPR119MGLLALKEPHX2 | |
| SCHEMBL14861962 | 0.81 | GPR119 (0.54) | GPR119MGLLALKEPHX2 | |
| SCHEMBL19023577 | 0.80 | GPR119 (0.51) | GPR119MGLLALKEPHX2 | |
| SCHEMBL19023579 | 0.80 | GPR119 (0.51) | GPR119MGLLALKEPHX2 | |
| SCHEMBL19023578 | 0.80 | GPR119 (0.51) | GPR119MGLLALKEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121703-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008020799-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |