Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.64 |
| ▸ | RECQL | P46063 | 5/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.64 |
| ▸ | FYN | P06241 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.64 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490593 | 0.82 | KDM6B (0.72) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL6382667 | 0.81 | KDM6B (0.70) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL18469325 | 0.79 | KDM6B (1.00) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL29350434 | 0.79 | KDM6B (1.00) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL29869020 | 0.79 | KDM6B (1.00) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL829784 | 0.79 | KDM6B (1.00) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL5691448 | 0.79 | KDM6B (1.00) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL9827020 | 0.78 | KDM6B (0.66) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| SCHEMBL17414653 | 0.78 | KDM6B (0.66) | KDM6BKDM4EHSD17B10TDP1ALOX15 | |
| Levodopa SCHEMBL20582239 | 0.78 | SLC7A5 (1.00) | KDM6BKDM4EHSD17B10TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125702-A1 | LEVODOPA DIMETHYL-SUBSTITUTED DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE | Xenoport, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008076458-A1 | LEVODOPA DIMETHYL-SUBSTITUTED DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE | XENOPORT, INC. (US) | 2008-06-26 | — | — | WO | disclosed |